Studies on Neurospora chromosome segment duplications (Dps) performed since the publication of Perkins's comprehensive review in 1997 form the focus of this article. We present a brief summary of Perkins's seminal work on chromosome rearrangements, specifically, the identification of insertional and quasiterminal translocations that can segregate Dp progeny when crossed with normal sequence strains (i.e., T × N). We describe the genome defense process called meiotic silencing by unpaired DNA that renders Dp‐heterozygous crosses (i.e., Dp × N) barren, which provides (...) a basis for identifying Dps, and discuss whether other processes also might contribute to the barren phenotype of Dp × N and Dp × Dp crosses. We then turn to studies suggesting that large Dps (i.e., >300 kbp) can allow smaller gene‐sized duplications to escape another genome defense process called repeat‐induced point mutation (RIP), possibly by titration of the RIP machinery. Finally, we assess whether in natural populations dominant RIP suppressor Dps provide an “RIP‐free” niche for evolution of new genes following the duplication of existing genes. (shrink)

For centuries, theologians and philosophers, among others, have examined the nature of religious experience. Students and scholars unfamiliar with the vast literature face a daunting task in grasping the main issues surrounding the topic of religious experience. The Cambridge Companion to Religious Experience offers an original introduction to its topic. Going beyond an introduction, it is a state-of-the-art overview of the topic, with critical analyses of and creative insights into its subject. Religious experience is discussed from various interdisciplinary perspectives, from (...) religious perspectives inside and outside traditional monotheistic religions, and from various topical perspectives. Written by leading scholars in clear and accessible prose, this book is an ideal resource for undergraduate and graduate students, teachers, and scholars across many disciplines. (shrink)

Hempel's Dilemma is the claim that physicalism is an ill-formed thesis because it can offer no account of the physics that it refers to: current physics will be discarded in the future, and we don't yet know the nature of future physics. This article confronts the first horn of the dilemma, and argues that our knowledge of current physics is sufficient for offering a physicalist ontology of the mind. We have good scientific evidence that future physics will be irrelevant to (...) the mind-body problem because mental processes lie safely within the well-understood domains of applicability of current physical theories. (shrink)

Equipoise is advocated as a means of achieving high scientific and ethical standards in randomised trials. As used in the context of research the word describes a state of uncertainty characterised by the belief that in a trial no arm is known to offer greater harm or benefit than any other arm. Clinicians who lack personal equipoise are advised to accept clinical or communal equipoise, based on current unresolved disagreement among the medical profession. Equipoise is mainly discussed in the literature (...) as an issue for senior doctors and research directors. Limitations of professional equipoise are reviewed, and data on the neglected topic of patients' equipoise are reported using the example of breast cancer trials. In theory, a patient who gives informed and voluntary consent to enter a randomised trial has achieved the equilibrium of equipoise. In practice, equipoise among patients ranges from personal to proxy acceptance. (shrink)

This article will examine McCormick's moral epistemology both at the level of how human persons know values and disvalues, which hereinafter will be referred to as synderesis, and at the level of how human persons know the rightness and wrongness of an action, which hereinafter will be referred to as normative moral judgment. On the one hand, from this investigation it appears that McCormick operates with a dual moral epistemology, at least at the level of synderesis. This means that at (...) one point in time it appears that a significant shift may have occurred in his moral epistemology at the level of synderesis. This may also be true at the level of normative moral judgment. On the other hand, McCormick's moral epistemology may in fact be a synthesis, which is the product of development and maturity in his thought process. This article will articulate, examine, and analyse both moral epistemologies. The first moral epistemology is operative in McCormick's writing up until 1983. The second moral epistemology corresponds to McCormick's decision in 1983 to write primarily in the area of bioethics from a theological perspective. Since the year 1983 seems to be the pivotal time when these two moral epistemologies converge, I will refer to the first moral epistemology as “prior to 1983” and I will refer to the second moral epistemology as “after 1983.” Because of the numerous criticisms that surround McCormick's moral epistemology, and the ambiguity that it entails, McCormick needed to articulate his theoretical foundations clearly and develop them systematically and coherently. Numerous moral theologians called for him to do this, yet he never responded. A systematic understanding of McCormick's moral epistemology is not only necessary but crucial in examining various issues in bioethics. It is necessary because it is the basis of moral decision making. It is crucial because the life and death of individuals may hang in the balance. (shrink)

The Nuremberg Trials of leading National Socialists established the principle that individuals may be legally punished, even by death, for obeying the laws of their country. Is there then a higher law by which enacted valid positive laws may be judged, so that persons subject to such laws would be duty-bound to defy them? In recent years the theory of natural law has been revived by a number of philosophers and jurists, who however often disagree sharply among themselves about the (...) proper methods for defining and deriving natural law. Howard Kainz surveys the history of natural law from its foreshadowing in ancient Greece down to the most recent controversies. Natural Law both introduces the subject to newcomers and sheds fresh light on such figures as Plato, Aristotle, Hume, Kant, Veatch, McInerny, Grisez, and Finnis. (shrink)

Context: This conceptual paper tries to tackle the advantages and the limitations that might arise from including second-order science into global climate change sciences, a research area that traditionally focuses on first-order approaches and that is currently attracting a lot of media and public attention. Problem: The high profile of climate change research seems to provoke a certain dilemma for scientists: despite the slowly increasing realization within the sciences that our knowledge is temporary, tentative, uncertain, and far from stable, the (...) public expectations towards science and scientific knowledge are still the opposite: that scientific results should prove to be objective, reliable, and authoritative. As a way to handle the uncertainty, scientists tend to produce “varieties of scenarios” instead of clear statements, as well as reports that articulate different scientific opinions about the causes and dynamics of change for this specific field of research. (shrink)

As the United States is currently prosecuting two wars, it is important to consider whether those wars, and the resulting noncombatantcasualties, can be morally justified. Such consideration can be initiated by considering some of Alan Donagan’s work in his book The Theory of Morality. In that book Donagan sets out to develop, as a philosophical system, that part of the common morality according to the Hebrew-Christian tradition, which does not depend on any theistic beliefs. According to that tradition it is (...) sometimes morally permissible to resort to war. This poses a problem because also part of the tradition is a near absolute prohibition on harming innocent people. Since innocent people die in war, there is a tension here.Donagan claims that this problem can be solved by assigning the blame for some such deaths to the aggressor, thereby permitting (some) resorts to war. This paper shows that this solution is inadequate; and defends a more plausible (and more traditional) justification for some innocent deaths. This justification is consistent with the system Donagan develops, and thus may have application in the consideration of the justification of the two wars currently being prosecuted by the United States. (shrink)

The article is concerned with the question of how legal institutions are structured with the use of constitutive, institutive, consequential, and terminative rules. To that end, the regulation of international treaties as laid down in the Vienna Convention on the Law of Treaties of 1969 is analysed. This leads to the discovery of two additional categories of rules: content rules and invalidating rules. Finally, the special status of unique legal institutions is investigated. Unique legal institutions – for example, heads of (...) state, parliaments, and supreme courts – enjoy validity in a legal system to the exclusion of the validity of any other legal institution of the same category in that system. (shrink)

1. Belief and mental statesDavidson holds that intentional verbs occurring in the form ‘A Vs that p’ signify propositional attitudes. These are, he claims, mental states, and dispositions. Davidson does not conceive of himself as introducing a special technical sense of the common intentional verbs. He insists that ‘the mental states in question are beliefs, desires, intentions, and so on, as ordinarily conceived'. Consequently he contends that believing that p is a mental state, disposition or dispositional state. These ontological claims (...) about the nature of belief inform his account of the logical form of belief sentences. I shall address the question of whether believing that p can justly be deemed a mental state, a disposition or dispositional state. Subsequently I shall examine Davidson's account of the logical form of belief sentences.Our concept of a mental state, like so many of the concepts which philosophers treat as categorial, is none too sharply defined. It has a respectable use, which can be described. But, like other such general psychological terms, e.g. ‘mental process’, ‘mental activity’, far from being the ‘hardest of the hard’ - a sharply circumscribed categorial term akin to a variable in a well-constructed formal system — it has blurred boundaries and is elastic. Like all our ordinary psychological concepts, it evolved in order to meet everyday needs. As Wittgenstein observed, ‘The concepts of psychology are just everyday concepts. They are not concepts newly fashioned by science for its own purposes, as are the concepts of physics and chemistry.’Although our ordinary concepts can be replaced by technical ones for specialized purposes, they cannot be abused without generating conceptual confusion and incoherence. If the expression ‘mental state’ is being employed in its ordinary sense, then it is wrong to hold that believing that p is to be in any mental state. If it is being employed in a special technical sense, then those who employ it thus owe us an account of what it means and how it is to be used. This Davidson and the many other philosophers who subscribe to the view that believing is a mental state have not done. Until such an account is forthcoming, one may presume that they think of themselves as deploying our ordinary concept of a mental state. And if so, I shall argue, they are misusing it. (shrink)

A questionnaire on the attitudes towards the functions of research ethical committees was sent to members of selected research ethical committees in Wessex and some controls. Almost all respondents felt there was a need for ethical review of research projects; 42 per cent thought there was a need for some training before joining a committee; 67 per cent thought the system could be improved and 47 per cent thought that monitoring or follow-up procedures should be adopted. Ethical committees were thought (...) to be purely advisory, as opposed to mandatory, by 33 per cent, and 63 per cent thought they should restrict their review to ethical problems as opposed to scientific or design problems. Views about the function of non-medical members ranged from 'none at all' to 'very important'. Of the 10 controls who were asked whether they would become a member of an ethical committee if asked, seven said that on balance they would and the reasons stated varied from the view that it was a 'very important committee' to the feeling that it was 'a necessary but irksome job'. (shrink)